Don’t wear a t-shirt or a shirt with short sleeves.Avoid hiding your birthmarks or scars – they need to be fully visible.Don’t make any faces – don’t frown, don’t smile – just keep your face as neutral as possible.Avoid white backgrounds as they are not permitted in any case.There are some things that you definitely have to avoid when it comes to taking and editing of your Philippine passport photo: What to avoid when it comes to Philippine passport photo No one else and no other things can be visible in the background of your Philippine passport photo.The background has to be of a royal blue color, it cannot have any patterns.It’s good to take your picture with natural light.You need to avoid shadows in your passport photo.There are also a few requirements concerning the background and the light in your Philippine passport photo: The resolution of the photo has to be over 600dpi.īackground & lighting requirements for Philippine passport photo.You will need two identical copies of the photo.The photo has to be 35mm in width and 45mm in height.There should be 5mm between the top of your head (including hair) to the top of the picture.Your head has to be the center of the passport photo and it should occupy around 70% to 80% of your photo.Here you can find some of the most important technical guidelines for a Philippine passport photo: Philippine passport photo size and specifications There is a dress code for a Philippine passport photo: you cannot wear short sleeves or a shirt with a big neckline – you need to wear a shirt with a collar and long sleeves (not a t-shirt).The only time that any type of headwear is allowed is when it’s worn for religious reasons. Your mouth has to be closed, your teeth shouldn’t be visible.Your prescription glasses can’t hide your eyes or reflect the light or your surroundings so make sure that they follow these guidelines or fully remove them.Your eyes have to be open, nothing can hide them so colored lenses and sunglasses are not allowed.You can’t smile or frown – your facial expression has to be kept as neutral as possible.Your head has to be fully visible, your facial features cannot be obstructed by anything. So how should you look in your Philippine passport photo? Below you can find some of the most important rules looks-wise:
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If you don’t want to settle for less than ZRemesher’s unequalled auto-retopology results and you’ve got some budget, I heartily recommend investing in Exoside’s Quad Remesher add-on for Blender. You can keep sculpting and press Control + Alt + R to remesh again using QuadriFlow. Experiment with different settings and values until you’re satisfied with the result. QuadriFlow can be activated via the Object Data Properties tab ➔ Remesh rollout ➔ Quad button. ZRemesher allows you to auto-retopologize a mesh with a more sophisticated result than a voxel remesher can.īlender doesn’t natively come with a tool that is on par with ZRemesher, but it offers an alternative to the Voxel Remesher called QuadriFlow, which can yield quite nice quad-retopology results that take the mesh curvature into account. One of the most-praised star features of ZBrush is ZRemesher. Once you’re satisfied with the Remesh settings, you can continue sculpting and press Control + R to remesh again using the same settings. To avoid this, uncheck Preserve Volume and remesh using a slightly lower Voxel Size value to maintain detail. The Voxel Size determines the resulting polygon detail, Fix Poles generates a slightly neater quadrangular topology, and Preserve Volume avoids details being smoothed out, although this can cause polygon artifacts in areas with sharp edges or crevices. In Sculpt Mode, click on Remesh and adjust the settings. This is a very useful feature that helps you avoid stretching of polygons as you keep sculpting new volume.īlender offers the Voxel Remesh tool as a Dynamesh alternative. ZBrush Dynamesh is mostly used in the concept stage of sculpting.ĭynamesh allows you to automatically remesh your sculpture using a voxel-based volume that’s projected as a 3D grid of polygons onto your mesh.
Let‘s analyze how it scares its audience: The Isolated Late-Night Gaming Setup The original Sonic.exe tale wastes no time building an atmosphere of dread. Breakdown of the Storytelling – Dissecting a Gamer‘s Nightmare This infectious trait supports the haunted game cartridge theory.īy combining beloved Sonic iconography with demonic corruption and infectious terror, Sonic.exe forms the perfect gaming creepypasta monster! Now let‘s see how the story brings this digital demon to life. Infectiousness – Like any virus, Sonic.exe seems able to transmit between technology and biological hosts. Unexplained Origins – Is Sonic.exe a demonic entity from another dimension? A malignant virus? Details about where this aberration came from and his motives remain unknown, leaving us to imagine the worst. He toys with victims like a cat with mice!ĭemonic Personality – He taunts and revels in causing chaos. Murderous Abilities – Sonic.exe displays unnatural powers from teleportation to reality manipulation, making him seem unstoppable. The jagged teeth and bleeding eyes signify he‘s out for blood! Twisted Physical Appearance -jet black fur and glowing red eyes signal this is no regular Sonic. Let‘s analyze the traits that define this creepy icon: When we see those crimson glowing eyes and razor-sharp blood-stained teeth, Sonic.exe makes an instant horrifying impression. This shadowy origin story adds to the mystique of Sonic.exe itself! Now let‘s examine the DNA of this disturbing digital demon… Anatomy of a Creepypasta Icon – The Character of Sonic.exe Inspired imitators but pioneer of iconic gaming creepypasta.Uploaded only one other pasta after Sonic.exe, then disappeared.Joined Creepypasta Wiki in 2011, same year Sonic.exe was posted.While Sonic.exe taps into these tropes, the original creator remains shrouded in mystery. Could Sonic.exe be inspired by this predecessor?īootleg Haunted Game ROMs – Creepypastas about possessed game cartridges like Polybius and Pokemon Black may have influenced the concept.ĭigital Urban Legends – The exe entity resembles digital demons from legends like Smile Dog and Suicide Mouse. Code gone rogue!Įarly Sonic SatAM Cartoon – In the dark 1990s Sonic cartoon, there was a robotic demonic Metal Sonic doppelgänger. exe file extension implies this is a malevolent entity transmitted through an executable computer program. A user named JC-The-Hyena uploaded the original story onto the notorious Creepypasta Wiki, kicking off the viral legend we know today.īut where did this darkened doppelgänger of Sonic really come from? Let‘s explore some of the potential roots: The nightmarish tale of Sonic.exe first emerged from the dark depths of the internet back in August 2011. But what is the real story behind this sinister hacked hedgehog? 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Mice with such human genes are technically human-animal hybrids.Įngrafting an immunodeficient mouse with functional human cells can be achieved by intravenous injections of human cells and tissue into the mouse, and/or creating a genetically modified mouse from human genes. To circumvent this limitation, the next development came with the introduction of transgenes encoding for HLA I and HLA II in the NSG RAG null model that enabled buildout of human T-lymphocyte repertoires as well as the respective immune responses. In accordance to this limitation, the human T cells when engrafted in the mice, failed to recognize human antigen-presenting cells, which consequated in defective immunoglobulin class switching and improper organization of the secondary lymphoid tissue. The limitation with this model was that it lacked the human leukocyte antigen. Researchers evolved this NSG model by knocking out the RAG1 and RAG2 genes ( recombination activation genes), resulting into the RAG null version of the NSG model that was devoid of major cells of the immune system including the natural killer cells, B lymphocytes and T lymphocytes, macrophages and dendritic cells, causing the greatest immunodeficiency in mice models so far. This accounted for the creation of the NOD- scid-γcnull mice (NCG, NSG or NOG) models which were found to have defective signaling of interleukins IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Nevertheless, a major breakthrough in this field came with the introduction of the mutant IL-2 receptor ( IL2rg) gene in the NOD- scid model. This mouse model permitted for a slightly higher level of human cell reconstitution. This resulted in the creation of the NOD- scid mice which lacked T cells, B cells, and NK cells. The next big step in the development of humanized mice models came with transfer of the scid mutation to a non-obese diabetic mouse. However, due to the retention of B cells and NK cells, they were unable to fully support engraftment of human immune cells, thus making them unsuitable as an ideal humanized mouse model. Commonly utilized strains included BALB/c-nu, Swiss-nu, NC-nu, and NIH-nu, which were extensively employed in the research of immune diseases and tumors. As a result, they did not exhibit a rejection response to allogeneic tissue. These mice primarily produced IgM and had minimal or no IgA. Nude mice were the earliest immunodeficient mouse model. In spite of the efforts in developing this mouse model, poor engraftment of human hematopoietic stem cells (HSCs) was a major limitation that called for further advancement in the development humanized mouse models. Dysfunctional PRKDC gene leads to impaired development of T and B lymphocytes which gives rise to severe combined immunodeficiency (SCID). A mutation in the Foxn1 gene on chromosome 11 resulted in impaired thymus development, leading to a deficiency in mature T lymphocytes. The PRKDC gene product is necessary for resolving breaks in DNA strands during the development of T cells and B cells. The first such mouse model was derived by backcrossing C57BL/Ka and BALB/c mice, featuring a loss of function mutation in the PRKDC gene. The discovery of the athymic mouse, commonly known as the nude mouse, and that of the SCID mouse were major events that paved the way for humanized mice models. Such mouse models have also become an integral aspect of preclinical biomedical research. To overcome these limitations and to realize the full potential of animal models to enable researchers to get a clear picture of the nature and pathogenesis of immune responses mounted against human-specific pathogens, humanized mouse models have been developed. Nevertheless, there are several incongruencies of these animal systems with those of humans, especially with regard to the components of the immune system. In particular, small animals such as mice are advantageous in such studies owing to their small size, brief reproductive cycle, easy handling and due to the genomic and physiological similarities with humans moreover, these animals can also be genetically modified easily. A lot of our knowledge about several human biological processes has been obtained from studying animal models like rodents and non-human primates. Ī humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the in vivo context for understanding of human-specific physiology and pathologies. Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics. Mouse carrying functioning human genes, etc.Ī humanized mouse is a genetically modified mouse that has functioning human genes, cells, tissues and/or organs. This resets the TeX installation to the initial state. Click Reset the TeX installation to factory defaults.Click Cleanup to navigate to the cleanup page.If you decide to uninstall MiKTeX, you should first reset the TeX installation to the factory defaults: If the proxy-server requires authentication (try with and without), set the other checkbox 'Authentication required' as well. 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